"Transfiguration is some of the most complex and dangerous magic you will learn at Hogwarts. Anyone messing around in my class will leave and not come back. You have been warned."
-- Minerva McGonagall
gotta go with this but potions is my second contender
"I don't expect you will really understand the beauty of the softly simmering cauldron with its shimmering fumes, the delicate power of liquids that creep through human veins, bewitching the mind, ensnaring the senses...I can teach you how to bottle fame, brew glory, even stopper death -- if you aren't as big a bunch of dunderheads as I usually have to teach."
-- Severus Snape
hmmm,my fave subject in Hogwarts would be Potions! i think brewing up things like The Draught of Living Death is so cool..plus,i want to make someone's filled cauldron explode too! (like how neville's cauldron accidentally exploded and a noxious potion spilled all over)
It would definitely be defence against the dark arts as you get to know how to defend yourself against various dark arts practices. There would also be hands on activities.